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HERDIN Record #: PCHRD18041014595086 Submitted: 10 April 2018 Modified: 13 April 2018

Association of blood level omega-3 fatty acids with risk of prostate cancer: A meta-analysis.

Michael E. Chua,
Mishell Sorongon-Legaspi,
Ma. Christina  Sio,
Marcelino  Morales Jr.

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OBJECTIVE: To generate the evidence for an association between blood level omega-3 polyunsaturated fatty acid (n-3 PUFA) and prostate cancer risk through a meta-analysis of epidemiological studies.
METHODS: MEDLINE, Unbound MEDLINE, EMBASE, Science Direct, OVID, Proquest and Cochrane Library databases up to September2011 were searched. All studies included described effect estimates of high blood level omega-3 FA on prostate cancer risk in humans. Critical appraisal was done by two independent reviewers. Data were pooled using the general variance-based method with random-effects model; derived effect estimates were expressed as risk ratio (RR) with 95% confidence interval. Heterogeneity was assessed by Chi? and quantified by F, publication bias was also determined using Begg and Egger's test.
RESULTS: Twelve epidemiological studies were included (6 prospective and 6 retrospective case control studies). The overall effect esti mate of blood level n-3 PUFA in general has no association with total prostate cancer, advanced prostate cancer and high grade tumor risk. Significant negative association was noted between high blood level of n-3 PUFA docosapentaenoic acid (DPA) and total prostate cancer risk(RR:0.756; 95% CI 0.599, 0.955; P=0.019); this finding was generated from homogenous studies (P=0.566; P=O%) with no publication bias. Likewise, a positive association was noted between high blood level of fish oil content n-3 PUFA, eicosapentanoic acid and docosahexanoic acid, (EPA+DHA) and risk of high grade prostate tumor (RR: 1.381; 95%CI 1.050, 1.817; P=0.02l); however, this finding was evident only after adjustment was done on inter-study variability through removal ofa lower quality study from the pool.Notably, a non-significant positive association was also found between high blood levels of alpha-linolenic acid (ALA) and total prostate cancer risk (RR: 1.188 ;95%CI 0.955, 1.477; P=0.123), with no significant heterogeneity (P=0.24, P=22%) nor publication bias.
CONCLUSIONS: This review provided evidence showing high blood levels of n-3 PUFA DPA is associated with reduced total prostate cancer risk. While high blood level ofEPA+DHA is associated with increased high grade prostate tumor risk. These findings warrant further clinical studies to clarify associations.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Surgical Specialties
Publication Date
July-December 2012
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 6 Fulltext pdf (Request Document)

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