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HERDIN Record #: NCR-PHC-18022214262035 Submitted: 22 February 2018 Modified: 22 February 2018

Association of non-alcoholic fatty liver disease with coronary artery disease.

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Background: Several risk factors for coronary artery disease(CAD) have been identified to guide physicians in preventing disease occurrence and managing disease progression. A novel factor considered to have significant risk in developing CAD is the non-alcoholic fatty liver disease(NAFLD).(1-3) Only a limited number of studies regarding association of NAFLD with presence and severity of CAD are available.(1,2,3)The objective of this study is to determine the association between non-alcoholic fatty liver disease and presence of significant CAD.

Method: Patients admitted for coronary angiography underwentperiprocedural liver ultrasound. Angiography results were subjected to Gensini scoring for severity determination. Results were subjected to descriptive statistics, t-test and logistic regression analysis.

Result: Ninety-one participants (males and females) who underwent coronary angiography at the Philippine Heart Center from October 2012 - March 2014 were included. Univariate analysis revealed that age, male gender, waist-to-hip ratio, diabetes mellitus, hypertension, smoking history, and the presence of NAFLD were significantly related to the presence of coronary artery disease on angiography. This study, however, showed that although there was a trend in the relationship between the presence of CAD and the finding of NAFLD on ultrasound it was not statistically significant.

Conclusion: This study was able to show that the finding of NAFLD on ultrasonography was related to the presence of CAD on angiography although statistical significance was not achieved. It was, however, also noted that despite the trend towards an increased risk for CAD, the presence of NAFLD was not related to the severity of the CAD noted.

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