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HERDIN Record #: NCR-PHC-17010414123673 Submitted: 04 January 2017 Modified: 04 January 2017

Diastolic dysfunction for post-operative atrial fibrillation (POAF) in coronary bypass graft (CABG) patients.

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Background. Post-operative atrial fibrillation (POAF) is a major cause of morbidity and mortality. It is associated with increased risk of stroke and death and constitutes asubstantial use of healthcare resources, including increased duration of hospitalization and hospital costs. No local studies so far investigating the relationship of left ventricular (LV) diastolic dysfunction and the incidence of post-operative atrial fibrillation in patients undergoing elective CABG surgery. The objective of this study was to investigate whether LV diastolic dysfunction was an important pathophysiological mechanism and predictor for the initiation of new-onset post-operative atrial fibrillation (POAF)

Methods and Rusults. This is a prospective cohort study involving patients undergoing elective CABG at the Philippine Heart Center from March 2014 to March 2015. Results showed that male sex (p=0.019) and hypertension (p=0.036) were significantly correlate with diastolic dysfunction. Echocardiographic findings that are correlated with diastolic dysfunction were LVEF (p=0.01), LVEDD (p=0.001), LA size (p=<0.001) and LAVI (p=0.001). We found out that there was high statistical correlation between the severity of diastolic dysfunction and the development of POAF in patients undergoing elective CABG (p=<0.001), with odds ratio of 4.97 (95% CI: 2.02-11.91, p=<0.001).

Conclusion. These results suggest that LV diastolic dysfunction is a powerful and independent predictor for the initiation and progression of POAF. Its evaluation may be useful in risk stratification and in the initiation of pre-operative treatment for POAF in patients undergoing elective cardiac surgery.

Publication Type
Research Project
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Philippine Heart Center Medical Library PHC.R.021.13 Fulltext Print Format

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