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HERDIN Record #: PCHRD1412150245250 Submitted: 15 December 2014 Modified: 15 December 2014

Rosai-Dorfman disease presenting as recurrent nasal polyposis

Neil Louis L. Apale,
Joel A. Romualdez,
Rodolfo E. Rivera

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OBJECTIVES: To present a case of Rosai-Dorfman disease in an individual with a 14-year history of recurrent nasal polyposis and discuss its clinical presentation, physical examination, radiologic findings, histopathologic characteristics and available treatment.

Design: Case Report
Setting: Tertiary Government Hospital
Patient: One

RESULTS: A 26-year-old Filipino diagnosed and repeatedly treated medically and surgically for recurrent nasal polyposis underwent repeat endoscopic sinus surgery. A histopathologic impression of Rosai-Dorfman disease was confirmed by positive S-100 and CD1a negative immunochemistry in conjunction with the morphologic findings.

CONCLUSION: Rosai-Dorfman disease is a rare entity which should be considered when dealing with recurrent nasal polyposis that is intractable to initial medical and surgical therapies. Histopathologic findings of emperipolesis and immunohistochemical S-100 stains play a key role in the diagnosis but there is yet no definite treatment for this disease.

Publication Type
Publication Sub Type
Case report
Philippine Journal of Otolaryngology Head and Neck Surgery
Publication Date
July-December 2014
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 64 Fulltext Print Format
Philippine Society of Otolaryngology-Head and Neck Surgery Abstract Print Format

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