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The effect of Dibencozide on under five children with poor weight gain.


Related Institution

Dept. of Pediatrics - Baguio General Hospital and Medical Center

Publication Information

Publication Type
Research Report


BACKGROUND: During preschool years, brain growth is slow with a decrease in nutritional requirements and decrease in appetite. With these, and other problems, children are often given multivitamins and or food supplements in the hope of improving appetite and eventually, weight gain. This is the first documented research that focused on the effect of dibencozide on older infants and preschoolers with poor weight gain.

METHODOLOGY: This is a prospective, randomized, double-blinded study undertaken in a tertiary hospital involving children aged six months to five years of age. The primary outcome variables were weight, height and calorie intake before and after six weeks of treatment. Data analysis was by descriptive statistics and independent T-test.

RESULTS: A total of 100 children were enrolled in the study. 59% complied and finished the research. The dibencozide group showed a significant increase in calorie intake compared to the placebo group (t = 2.085, t05 = 2.064). Furthermore, there was a significant difference in weight gain (t = 2.915, t05 = 2.0) and height increase (t = 0.883, t05 = 1.96) in children who took dibencozide. There was no significant weight gain after discontinuance of its use. One patient experienced diarrhea during the duration of the study.

CONCLUSION: With the use of dibencozide in this study population, there was a significant increase in appetite, actual calorie intake and a much higher than expected calorie increase per month as compared to the placebo group. There was significant weight gain and increase in height after intake of dibencozide. The drug was generally well tolerated with no significant side effects. Therefore, dibencozide (Heraclene) is effective as an appetite enhancer and is recommended for children with poor weight gain.


OBJECTIVES: To determine the efficacy of dibencozide on children aged six months to five years old with poor appetite and poor weight gain. Specifically, it aims to prove the effectiveness of dibencozide as an appetite stimulant. To establish its effect on weight gain, the maintenance of this gain in weight even after its discontinuance and height.


1. Bustamante, C. . "The efficacy of Dibencozide on growth of low birth weight infants" Journal of pediatrics , 1998
2. Nelson, Kliegman . Nelson textbook of pediatrics WB Saunders, 2000. 32-52.
3. Nutritional guidelines for filipinos DOST, 2000. 33-37.
4. Heraclene drug literature Natrapharm,
5. See how they grow

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Baguio General Hospital and Medical Center Fulltext Print Format

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