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HERDIN Record #: PCHRD08161109081520 Submitted: 16 August 2011 Modified: 16 August 2011

Clinical spectrum of Hepaptitis C virus infection in the Philippines Molecular Virological aspects.

Mary Ann D. Lansang

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Publication Type
Research Project


General Objectives: Investigate the particular aspects of chronic HCV infection among Filipinos using tools in molecular virologySpecific Objectives: 1. Establish a quantitative PCR-HCV method for determining viral load and correlate this with anti-HCV positivity as well as clinical diseases2. Undertake extensive HCV genotyping among chronic HCV carriers and correlate the genotype with severity of the disease, mode of infection and response to IFN-treatment.3. Establish a heteroduplex mobility assay (HMA) for assessing quasi-species heterogeneity in chronic HCV cases and correlate this with probable duration of infection.

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