Bio-assay procedures for medicinal plants already demonstrated to posses clinical efficacy by the Rapid Clinical of the Integrated Herbal Medicine Program shall be studied. Different experimental techniques assessing the pharmacologic effects shall be tried out to determine which one is the most appropriate for quality control at the regional manufacturing plants. Quantitative assessment of pharmacological potencies shall be based on dose-response relationships utilizing both in vitro and in vivo experimental set-ups. Experimental runs with medicinal plant products will have negative and positive controls. Standard drugs with known pharmacologic activity for the specific pharmacologic effect being measured shall be utilized as positive controls.
The sensitivity, specificity, reproducibility and simplicity of the different methods shall be compared to select which one will be most appropriate for application in regional manufacturing plants. Eight batches of yerba buena extracts were tested for analgesic activity using the analgesic order. The initial tests showed no significant activity. The results were not conclusive since the controls turned out to be inadequate. Yerba buena dry leaves did not show analgesic activity in one trial but no conclusion was derived because two more trials are needed. Batches of tsaang-gubat dried leaves were tested for anti-diarrheal activity using the charcoal tracing method and the results were positive.
The study aims to establish bioassay quality standard procedures for assessing adequate pharmacologic potencies of medicinal plant products. The specific objectives are: 1) to perform subchronic toxicity and histopathologic studies on sambong tablets and initial chronic toxicity study of lagundi tablets, and 2) to perform services for bioassay tests on sambong tablets, ulasimang bato, and ampalaya tops/tablets.
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