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HERDIN Record #: PCHRDPC990198 Submitted: 16 May 2007 Modified: 01 July 2020

Sotalol in the management of ventricular arrhythmias in Filipino subjects.

William T. Chua,
Antonio L. Dans,
Felix Eduardo R. Punzalan Jr,
Belen O. Carisma

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Sotalol (d.l. sotalol), a beta-blocker with class III anti-arrhythmic property, was tested in a prospective, open-label dose escalation study involving Filipino subjects with symptomatic or complex ventricular arrhythmias to determine the dosage range that would led to adequate control of arrhythmias, defined as a reduction in the frequency of isolated premature ventricular contractions (PVCs) at least 70% or reduction of couplets or repetitive firing by 90% based on 24-hour ECG monitoring. Patients were treated with oral sotalol, titrated within the dosage range of 160-480 mg/day over an observation period of 42 days. Analyses of the study results were focused on the percentage of patients that achieved arrhythmia control, the range of dosage schedules which lead to arrhythmia control, and the adverse events observed during treatment. A total of 46 subjects were enrolled, 44 (36 females; 8 males, average age, 43) of whom comprised the final study population. At the starting dose of 160 mg/day, arrhythmia control was achieved in 16 of the 44 subjects (36%). At the dose of 320 mg/day, 13 of 26 patients (50%) titrated to that dose achieved arrhythmia control. Overall, arrhythmia control was achieved in 30 of the 44 subjects (68%), a relatively high figure comparable with figures in other studies. Adverse events were infrequent. Three patients were withdrawn (2 because of possible pro-arrhythmia; 1 because of weakness). Two subjects dropped out for unknown reasons.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
October-December 1998
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Philippine Council for Health Research and Development Box No. 44 Fulltext Print Format
Philippine Council for Health Research and Development Fulltext pdf (Request Document)
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