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HERDIN Record #: PCHRDPC940680 Submitted: 16 May 2007 Modified: 19 August 2020

Electrophysiologic and anatomic substrate for paroxysmal atrial fibrillation.

Jo Ann S. Lao ,
Raul Lastimosa ,
William T. Chua

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The mechanism initiating paroxysmal atrial fibrillation (PAF) has been shown to be triggered by spontaneously occurring atrial premature contraction (APC). The ability of the coupling index of the APC and underlying anatomic pathology to influence the onset of the arrythmia was analyzed in this study Included were randomly selected 14 consecutive patients, who on 24-hour Holter monitoring, demonstrated PAF triggered by APCs with shorter coupling indices. The second group of randomly selected 14 consecutive patients showed longer coupling indices of APC without subsequent PAF initiation. However, occasional shorter coupling indices were observed without PAF initiation. The echocardiographic studies of the forer group showed a variety of anatomic pathology ranging from regional wall motion abnormally to valvular nature. In contrast, all patients in the second group had normal echocardiographic studies. It is concluded in this study that coupling indices of APC per se do not take all credence but an underlying anatomic substrate remains a major pivotal framework for initiating PAF.

Publication Type
Publication Sub Type
Journal Article, Original
Philippine Journal of Cardiology
Publication Date
July-September 1993
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Box No.44 Fulltext pdf (Request Document)
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