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HERDIN Record #: PCHRD051408030540 Submitted: 14 May 2008 Modified: 12 April 2018

A systematic overview on controversies in the diagnosis and management of follicular carcinoma of the thyroid.

Edgardo R. Cortez,
Isaac David E. Ampil II

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The diagnosis and management of well-differentiated thyroid cancer, especially follicular cancer, remains controversial. Since clinical trials are impractical and unavailable, we comprehensively searched and appraised the literature for the best available evidence to determine whether follicular cancer can be differentiated from adenoma by frozen section, the predictors of aggressive tumor behavior, the role of total thyroidectomy in improving prognosis, the incidence of complications following total thyroidectomy and the adjuvant therapeutic modalities that can control the disease. From level 2 evidence, we found that frozen section using multiple sectioning of the nodule can accurately differentiate benign adenoma from follicular carcinoma. Age, tumor size and extent of disease were the most consistent predictors of risk. Total thyroidectomy decreased recurrence but had equivocal effect on survival. The incidence of permanent complications following thyroidectomy ranged from 5-7 percent in tertiary centers. Postoperative thyroid stimulating hormone (TSH) suppression and radioactive iodine (RAI) therapy seemed to improve survival. (Author)

Publication Type
Publication Sub Type
St. Luke's Medical Journal
Publication Date
January-June 2005
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Fulltext Print Format
UERMMMC Fulltext pdf (Request Document)

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