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A Randomized, Double-Blind, Double Dummy, Parallel Group, Multicenter 24 to 52 Week Variable Length Study to Assess the Efficacy and Safety of Budesonide, Glycopyrronium, and Formoterol Fumarate Metered Dose Inhaler (MDI) Relative to Budesonide and Formoterol Fumarate MDI and Symbicort® Pressurized MDI in Adult and Adolescent Participants with Inadequately Controlled Asthma (KALOS)
Adult and Adolescent Participants with Inadequately Controlled Asthma
A prospective, randomized, open-label, comparative study to assess the efficacy, safety and tolerability of aztreonam-avibactam (ATM-AVI) and best availability therapy for the treatment of serious infections due to multi-drug resistant gram-negative bacteria producing metallo-β-lactamase (MBL)
Primary Outcome Measures:1. Proportion of subjects with clinical cure in the microbiological Intent-To-Treat (micro-ITT) analysis set [Time Frame: Up to 31 day ]Proportion of subjects with clinical cure at the TOC visit in the micro-ITT analysis set
Serious bacterial infection
Characteristics of musculoskeletal signs and symptoms during the recovery phase of moderate to severe COVID-19 patients at the Philippine General Hospital
This is a prospective observational descriptive study of moderate to severe COVID-19 aged 18 years old and above at UP PGH. It was done in phases: an exploratory phase to determine common signs and symptoms coming from patient reports. These signs and symptoms were then used to develop an appropriate structured questionnaire or assessment tool, which has undergone translation and validation. We implemented the tool over a cohort of 40 patients in their recovery phase from moderate to severe COVID-19, two weeks after clinical improvement or testing negative from Covid-19.
A 12-week, multicenter, randomized, double-blind, parallel-arm, placebo-controlled study to assess the efficacy and safety of CSJ117, when added to existing asthma therapy in patients ≥18 years of age with severe uncontrolled asthma
Average change from baseline in pre-dose FEV1 (L) at Week 8 and Week 12.
severe uncontrolled asthma
A Phase 1, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, First-In-Human Study Evaluating the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of AK119 in Healthy Subjects and Patients with Mild or Moderate Symptoms of COVID-19
Healthy Subjects and Patients with Mild or Moderate Symptoms of COVID-19
A Phase 1b Randomized, Double-blind, Placebo-controlled, Multiple Ascending-dose Study of EQ001 in Subjects with Systemic Lupus Erythematosus with or without Active Proliferative Lupus Nephritis
Safety and tolerability of EQ001, as assessed by treatment-emergent adverse events (TEAEs), treatment-emergent serious adverse events (TESAEs), clinical laboratory values, vital signs, 12-lead electrocardiogram (ECG), and physical examinations
Systemic Lupus Erythematosus with or without Active Proliferative Lupus Nephritis
Well-being and Exergaming
Well-being is defined by a person's feelings, positive functioning, and evaluation of self-fulfillment or satisfaction with life [1,2]. A person's feelings should involve positive emotions and moods (e.g., contentment, happiness) and fewer negative emotions (e.g., depression, anxiety) . Well-being is primarily focused on six thematic dimensions: physical well-being, emotional well-being, psychological well-being, social well-being, spiritual well-being, and activities and functioning . Age can substantially influence well-being; as people get older, they become more vulnerable to physical, psychological, and social factors, predisposing them to musculoskeletal disorders and other conditions . In addition, older adults may lack interest in leisure activities due to physical limitations, leading to diminished social integration  and fostering loneliness and affecting their mental health . Overall, the well-being of these individuals is often overlooked and not prioritized.
1. Camitan DS, Bajin LN. The Importance of Well-Being on Resiliency of Filipino Adults During the COVID-19 Enhanced Community Quarantine: A Necessary Condition Analysis. Frontiers in Psychology 2021;12:1–13.
2. nef. Measuring Well-being A guide for practitioners Measuring Well-being 2.
3. Linton M, Dieppe P, Medina-Lara A. Review of 99 self-report measures for assessing well- being in adults: exploring dimensions of well-being and developments over time. BMJ Open 2016;6, DOI: 10.1136/BMJOPEN-2015-010641.
4. Briggs A, Cross M, Hoy D et al. Musculoskeletal Health Conditions Represent a Global Threat to Healthy Aging: A Report for the 2015 World Health Organization World Report on Ageing and Health. The Gerontologist 2016;56:S243–55.
5. Toepoel V. Ageing, Leisure, and Social Connectedness: How could Leisure Help Reduce Social Isolation of Older People? Social Indicators Research 2013;113:355.
6. Stephens C, Alpass F, Towers A et al. The Effects of Types of Social Networks, Perceived Social Support, and Loneliness on the Health of Older People: Accounting for the Social Context. Journal of Aging and Health 2011;23:887–911.
A Phase III, Randomized, Double-Blind, Placebo-Controlled, Multi-Center Study of Durvalumab Monotherapy or in Combination With Bevacizumab as Adjuvant Therapy in Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation (EMERALD-2)
Recurrence-free survival (RFS) using Blinded independent central review (BICR) assessments according to Response Evaluation Criteria in Solid Tumors (RECIST) 1.1
Patients With Hepatocellular Carcinoma Who Are at High Risk of Recurrence After Curative Hepatic Resection or Ablation
Prospective, Non-Randomized, Open-Label, Multi-Center, Single Arm Study of Exchange of Travoprost Intraocular Implant
Primary outcome is to evaluate the safety of the surgical exchange procedure of Travoprost Intraocular Implant
This study is for the treatment of Open-Angle Glaucoma
A Phase 2, Randomized, Observer-Blind, Multicenter Study to Evaluate the Immunogenicity and Safety of Several Doses of Antigen and MF59 Adjuvant Content in a Monovalent H5N1 Pandemic Influenza Vaccine in Healthy Pediatric Subjects 6 Months to < 9 Years of Age
H5N1 pandemic influenza