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HERDIN Record #: PCHRDHE912349 Submitted: 16 May 2007 Modified: 24 April 2019

Field trial of sulfamethopyrazine and pyrimethamine in Philippine P. falciparum.

 Angeles Virgilio

The place of drugs in malaria programmes is indispensably necessary notwithstanding the availability of residual insecticides. Even when such chemicals can be successfully applied over stricken areas, drugs are equally required to deplete the parasite reservoir and prevent the re-establishment of transmission.

It is on this premise that the Philippine Malaria Service has embarked on a drug study with the view of supplementing its present anti-malarial drugs and especially on account of the emergence of resistant P. falciparum to chloroquine.

With this in mind it was envisioned therefore by the national malaria service to conduct a field trial on Metakelfin which is a drug combination containing 500 mg. of sulfametopyrazine and 25 mg. of pyrimethamine as a possible alternative drug in its present campaign.

This study was conducted in eight localities in the Municipality of Montalban, Rizal province for a period of 10 months or from September 1977 to July 1978. Montalban is an endemically malarious areas as evidenced by its annual parasite incidence (API) of 6.1 per 1000 population and a slide positivity rate (SPR) of 2.8% one year prior to this study. Based on this malaria incidence all the localities thereon are subjected to a regular 6 months interval of DDT spraying which is the principal measure implemented in the present malaria programme.

The procedures followed in this test were guided by a protocol which specifically touches on the selection of the test area and subjects as well as the intervals for the smearing and examination of each of the test slides.

The determination of the parasite densities of each of the positive smears is also provided in the protocol as a measure of ascertaining the effect of the drug after its administration.

Briefly, the results in this field trial of Metakelfin on P. falciparum cases is encouraging, wherefore, its use could be of unquestionable help to the malaria programme.(Auth. Abs.)

Publication Type
Publication Sub Type
The Philippine Journal of Microbiology and Infectious Diseases
Publication Date
July-December 1979

Publication Type
Publication Sub Type
10th International Congress on Tropical Medicine and Malaria Abstracts
Place of Publication
November 9-15, 1980
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library R-3892 Abstract Print Format