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HERDIN Record #: NCR-JRRMMC-06141203064823 Submitted: 14 June 2012 Modified: 14 June 2012

Iatrogenic hypopituitarism: A Case report.

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Various abnormalities of or trauma to the pituitary gland or hypothalamus can cause hypopituitarism. Resultant hormonal deficiencies may be partial and may take years to develop fully. Therefore, the clinical picture is often subtle and may include numerous manifestations depending on the hormones involved and the patient's age at onset.

The purpose of this report is to describe a case of a man with an iatrogenic cause of hypopituitarism.


STUDY SETTING: Tertiary Government Hospital

A 39 year-old male with pituitary tumor that underwent transphenoidal surgery followed by radiation therapy later on presented with a 4-year history of slowness in speech, mental dullness accompanied by progressing bipedal and facial edema.

Signs and symptoms presented by the patient with a decreased values of T4, TSH is highly compatible with secondary hypothyroidism. Although results of FSH and LH (gonadotropins) levels were not documented, decrease in libido with impotence and absence of axillary and pubic hair is highly compatible with gonadotropins deficiency. The absence of pigmentation of skin and pallor with documented decreased values of cortisol is compatible with ACTH deficiency. She was then treated with oral glucocorticoid replacement using hydrocortisone or prednisone in equivalent doses followed by thyroid hormone replacement.

Publication Type
Research Report


To describe a case of hypopituitarism according to its clinical presentation, particular cause and management.

LocationLocation CodeAvailable FormatAvailability
Medical Library, 5/F Training and Research Office, Jose R. Reyes Memorial Medical Center 01-1 #32 Abstract Print Format

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