Wound healing in burn cases are delayed mostly because the devitalized tissue acts as a subsrate for the prolification of microorganisms.Topical bum ointments that are bacteriostatic would greatly enhance the healing of these wounds.Silver Sulfadiazene is a recognized topical chemotherapeutic agent effective in managing burns.However,studies regarding the effects of topical application of annatto in comparison with silver sulfadiazene are very limited.It is for this reason that this study was conceived.Ten healthy albino rats weighing 180-250 grams each were used as subjects for the study.Each rat was shaved at the dorsum.The first wound located cephalad was applied with annatto seeds,the second wound was applied with silver sulfadiazene,the last wound was applied with NSS which served as the control.The diameter of the wounds were measured daily,after which,histological specimens were sent for histopathologic evaluation.Macroscopic findings have showed that annatto seeds, silver sulfadiazene and NSS al1 exhibited diminished wound area. Microscopically however,Annatto seed. paste showed similar histopathologic patterns as compared to silver sulfadiazine.Furher statistical treatment regarding the inflammatory reaction showed an insignificant value between silver sulfadiazene and annatto seed paste.It has been concluded in this study that annatto seed paste therefore,can be used for the topical treatment of burns,as there is no significant difference between the use of silver sulfadiazene and annatto seed paste.
To determine the efficacy of Annatto seed paste applied topically on burn wounds compared to silver sulfadiazine.
1.To determine the effect of annatto seed paste and silver sulfadiazine in wound diameter when applied topically on burn wounds in rats 3,6 and 9 days.
2.To determine the effect of annatto seed paste and silver sul1adiazine in the depth of inflammatory cell formation when applied topically on burn wounds in rats at 3,6 and 9 days.
3.To determine the effect of annatto seed paste and silver sulfadiazine in the extent of inf1ammatory reaction when applied. topically on burn wounds in rats at 3 and 9 days.
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