Tamarindus indica (Tamarind) extract has been used in traditional medicine in many countries.It has peaked some interest as an anti-inflammatory.The purpose of this study is to determine the anti-inflammatory fruit extracts of 50 percent,75 percent,and 100 percent ethanol and compare its anti-inflammatory activity to that of intra-peritoneally introduced indomethacin using the inhibition of Carrageenan induced mouse paw edema model.Our results show that only the 100 percent ethanol extract of tamarind has significant anti-inflammatory property. On the 3rd hour after inflammation was induced, there was a 39.91 percent inhibition of inflammation when compared to that of the negative control. Also in the 3rd hour, the extract has 100 percent anti-inflammatory activity of indomethacin. Unfortunately the positive and the negative controls are not significantly different. So no conclusion can be made and the results are thus inconclusive.