Studies on Selected Medicinal Plants in Mindanao

PHRR121108-000013

Extraction, Purification and Preliminary Toxicity and Antioxidant Potential Assessment of the Phytochemicals from Selected Medicinal Plants of Mindanao

This project is part of the first phase of a program which ultimately aims to produce herbal preparations or pure therapeutic drug leads sourced out from medicinal plants found in Mindanao. The first phase of this program is exploratory and holistic in nature in the sense that all plant extracts will be subjected to general bioassays (cytotoxicity, antioxidant, antimicrobial, DNA-binding, genotoxicity and adulticidal) which are correlated with important diseases (cancer, infectious diseases including MRSA, TB and malaria). Bioassay-guided fractionation and purification will ensue for “active” extracts after evaluation of their bioactivities. Identification of the active components will then follow. For this project, three studies are involved: Study 1: Extraction and Purification of the Phytochemicals Study 2: Toxicity Screening of the Crude Extracts Study 3: Evaluation of the Comparative In Vitro Antioxidant Potentials of the Crude Extracts

Regime Classification Priority
2010 - 2016 Health Technology Development Drug Discovery and Development
Start Date Duration in Months Target Completion Date Actual Completion Date
2012-06-01 12 2013-06-01 0000-00-00

Ongoing

Institution Classification Region LTO #
Mindanao State University - Iligan Institute of Technology, College of Science and Mathematics Public Higher Education Institution - State Universities and Colleges Region X
Institution Region
Philippine Council for Health Research and Development, Department of Science and Technology NCR
Name E-Mail Institution and Institution Address
Dr. Mylene M. Uy mylene603@yahoo.com Chemistry Department, MSU-Iligan Institute of Technology, Andres Bonifacio Avenue, 9200 Iligan City
Name E-Mail Institution and Institution Address
Dr. Mylene M. Uy mylene603@yahoo.com Chemistry Department, MSU-Iligan Institute of Technology, Andres Bonifacio Avenue, 9200 Iligan City
Name Expertise Affiliation
Anita P. Rivera Biochemistry Mindanao State University - Iligan Institute of Technology, College of Science and Mathematics
Mylene M. Uy, PhD Natural Products Chemistry Mindanao State University - Iligan Institute of Technology, College of Science and Mathematics
Name of Trial Site Address Principal Investigator Research Ethics Committee
NAME EXPERTISE REC Name Status of Approval
Mindanao State University - Iligan Institute of Technology, College of Science and Mathematics Chemistry Department, MSU-Iligan Institute of Technology, Andres Bonifacio Avenue, 9200 Iligan City Anita P. Rivera Biochemistry
Mindanao State University - Iligan Institute of Technology, College of Science and Mathematics Chemistry Department, MSU-Iligan Institute of Technology, Andres Bonifacio Avenue, 9200 Iligan City Mylene M. Uy, PhD Natural Products Chemistry

Non-clinical Studies

cancer, infectious diseases including MRSA, TB and malaria

Unspecified

Unspecified

Unspecified

  • Philippines

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