Background. Stevens-Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and SJS/TEN overlap are medical emergencies, with no current consensus on their proper management. Philippine studies are few and due to increasing incidence, determination of the epidemiologic and clinical characteristics are needed.
Objective. The study aims to determine the epidemiologic characteristic features, etiology and outcomes of SJS, SJS/TEN overlap and TEN patients.
Methods. Medical records review of SJS. SJS/TEN overlap or TEN cases in St. Luke's Medical Center, Quezon City from
2007-2011 was done to determine the means, percentages and proportions of the epidemiologic data and clinical characteristics.
Remits. Thirty-two of 52 medical charts were reviewed. There are equal proportions of male (N=16) and female (N=16) patients. SJS accounts for 75% (N=24) of cases. SJS, SJS/TEN overlap and TEN cases involve patients who are 40 years old and with hypertension. Allopurinol is the most common causative agent. TEN cases have the longest duration of hospital stay and with the shortest onset of dermatologic symptoms, appearing on the body only. Mortality is low but is associated with several common complications. Skin punch biopsy was done in 16.66% (N=4) of SJS cases. The combination of steroids and antibiotics is the most commonly used management regimen. Mortality is 4% in SJS, 25% in SJS/TEN overlap, and none in TEN.
Conclusion. Allopurinol is the most common causative agent in our institution. Concomitant co-morbidities, length of hospital stay and types of management may affect the mortality and prognosis of patients.
Key words. SJS, toxic epidermal necrolysis, SJS/TEN overlap