A hospital-based cross-sectional study was conducted to e aluate the association between catechol-0-methyltransferase COMT) and CYP2D6* I 0 single nucleotide polymorphisms (SNPs) and opioid consumption among cancer pain patients. COMT and CYP2D6* 10 genotyping was performed by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP). In this study, there was no association noted between COMT genotype and dosage of morphine. The odds of moderate to high morphine use among patients with Val/Val genotype were I. 78 times higher compared to those with Val/Met genotype. For CYP206* 10
S Ps, there was no association noted when various doses of tramadol were compared against the three CYP206* 10 genotypes (Homozygous CIC; Heterozygous CIT and Homozygous TIT). In conclusion, there was no association een in both the pain candidate genes, COMT (Vall 58Met) and CYP2D6* l 0 (Pro34Ser) and opioid use among cancer pain patients.
Key words. COMT; CYP206* l O; Cancer Pain; SNPs; Opioids