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Submitted: 12 May 2017 Modified: 12 May 2017
HERDIN Record #: NCR-PHC-17051214035235

Contrast-induced nephropathy in patients with normal serum creatinine undergoing contrast enhanced computed tomography: a comparison of Iodixanol and Iopamidol.

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Background: Contrast induced nephropathy (CIN) is defined as the acute decline in renal function that occurs 48-72 hours after intravascular injection of contrast medium and may be affected by osmolality of the contrast media. This study seeks to compare changes in glomerular filtration rate and incidence of CIN in contrast media of different
osmolality.


Method and Results: This is a prospective cohort of 90 adult patients with contrast enhanced CT scan using iodixanol (n= 34) or iopamidol (n=56) with a normal baseline serum creatinine. CIN was defined as greater then 25% increase in serum Creatinine from baseline or a 0.5 mg/dL (44 umol/L increase in the absolute value within 48-72 hours of intravenous contrast administration. Results: There was no association between type of contrast media and incidence of CIN (p=0.39). There is no significant difference in the mean change in serum creatinine and eGFR (Cockcroft-Gault/MDRD) between the two groups (p=0.224,0.630, and 0.333 respectively).


Conclusion: The osmolality of contrast media is not associated with incidence of contrast induced nephropathy.

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Research Project
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Philippine Heart Center Medical Library PHC.R.007.14 Fulltext Print Format

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