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Submitted: 20 March 2017 Modified: 22 March 2017
HERDIN Record #: NCR-PHC-17032014153727

Association of the intima-media thickness of the common carotid artery bypass and brachial artery flow-mediated dilation with the extent, severity, and jeopardy score of coronary artery disease.

Alex T. Junia,
Ma. Teresa B. Abola,

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Background: Measurement of the carotid artery intima-media thickness (IMT) assesses the extent and severity of atherosclerosis. It is directly correlated with cardiovascular disease affecting the cerebral, peripheral, and coronary artery vascular beds. Vascular endothelial function exemplified by flow-mediated dilation (FMD) plays a pivotal role in the pathogenesis of atherosclerosis and enhances the risk of future cardiovascular events.


Materials and Methods: Forty-six patients who underwent coronary angiography at the Philippine Heart Center (PHC) had quantitative measurement of the distal common carotid artery IMT and brachial artery FMD. Relation between carotid artery (IMT) and brachial artery FMD with the extent , severity, and jeopardy scores of CAD.


Results: There were 40 (87%) men and 6 (13%) women included in the study with a mean age of 60 ± 11 years. Seven patients (15.7%) had no coronary vessels with 370% stenosis  and 26 (56.5%) had three-vessel disease. The mean extent of CAD  score was 28.87 ± 15.08 (range, 0 t0 64.5). The mean jeopardy score was 7.70 (range, 0 to 12). The mean maximum IMT of the distal common carotid artery was significantly correlated with the extent score of CAD IMT (r=0.039, p=0.0370 but was not significantly correlated with the severity and jeopardy scores of CAD. Age and the number of pack-years in the smoking history were found to be significantly correlated with the maximum IMT (r=0.417, p=004 and r=0.321, p=0.030) but not with the extent and jeopardy scores of CAD.


Conclusion: This study shows a significant positive correlation between the mean maximum IMT of the war wall of the distal common carotid artery with the extent score of CAD, age and the number of pack-years in the smoking history.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
Philippine Heart Center Journal
Frequency
Annual
Publication Date
January-December 2003
Volume
10
Page(s)
29-33
LocationLocation CodeAvailable FormatAvailability
Philippine Heart Center Medical Library Fulltext Print Format
 

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