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Submitted: 12 May 2016 Modified: 12 May 2016
HERDIN Record #: NCR-PHC-16051211190960

High Sensitivity C-Reactive Protein (hsCRP) as a Biomarker of Treatment Response After the Intensive Phase Among Pediatric Patient With Tuberculosis.

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Background: Childhood tuberculosis has an increasing incidence worldwide. Its occurrence represents an important event indicating a recent transmission usually from an infectious adult. The identification of a surrogate biomarker for treatment response and risk for poor outcome in tuberculosis will be a beneficial tool in the patient's management. Thus, a biomarker like high sensitivity C-reactive protein (hsCRP) was proposed to be a prognostic marker.


Method: Children diagnosed with tuberculosis based on the Philippine Pediatric Society and National Tuberculosis Program guidelines were included in the study. Clinical data were reviewed and recorded, and blood samples were collected for serum hsCRP determination at 2 point of time (before treatment, and after the intensive phase). Data analysis was done using Stata SE version 12. Mean, standard deviation, frequency, percent distribution, paired T test and scatter plot were used. The level of significance is set at 0.05.


 Results: There were 40 subjects diagnosed with pulmonary tuberculosis who participated the study. Twenty-three were male (57.5%) and 17 were female (42.5%). The age ranges from 1 to 18 years with a mean age of 8.6 ± 5.5. Out of the 40 participants, 32 had completed the study. In this study, the analysis of data showed that the level of serum hsCRP after the intensive phase of  treatment is significantly lower compared to the level before treatment (p value of 0.0002). On the other hand, body mass index (BMI), which is being used as one of the objective parameters of treatment response in children, demonstrated a statistically significant difference before and after the intensive phase at a p value of 0.0007. High sensitivity C-reactive protein and BMI were indirectly correlated, however, it is statistically insignificant.


Conclusion: This study has shown that there is a statistically significant lower serum hsCRP level after the intensive phase of treatment among pediatric patients with tuberculosis. It is therefore concluded that hsCRP can be an additional parameter to evaluate treatment response as early as 2 months of treatment.

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Research Project
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Philippine Heart Center Medical Library PHC.R.020.14 Fulltext Print Format

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