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Submitted: 11 April 2016 Modified: 11 April 2016
HERDIN Record #: NCR-PHC-16041111102380

Prevalence of Family History of Premature Coronary Artery Disease in Patients with Coronary Artery Disease.

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Background: Family history of Coronary Artery Disease is considered a major risk factor in disease development not only because of inherited susceptibility genes, but also because of shared lifestyles that may exacerbate individual susceptibility to CAD. This study aimed to determine the presence of family history premature CAD and assess its impact on CAD risk, independent of established risk factors like age, hypertension, diabetes mellitus, hyperlipidemia and smoking history.


Methods: Available registry data of patients with Coronary Artery Disease and admitted in the Philippine Heart Center was retrieved from each Division of the Department of Education, Training and Research of the Philippine Heart Center. Patient charts were then retrieved for review. Patients' age, gender, co-morbid illness, smoking history, family history of premature CAD, previous history of Acute Coronary Syndrome, and treatment modality for Acute Coronary Syndrome (PCI/OMT/CABG) will be recorded. Data was then analyzed using rates, ratios, percentages, and paired t-test.


Results: Family history of premature CAD reduced the age of onset of coronary artery disease. The mean age of CAD diagnosis was 61.6 years as compared  to 62.3 years for the negative family history of premature CAD patient category. This study likewise showed consistently that smoking history (p value 0.045) and history of previous ACS (p value 0.012) had associations with family history of premature CAD and were strong predictors of CAD.


Conclusion: Family history of premature CAD increased the risk of development of myocardial infarction. This study likewise showed that with history of premature CAD, prevalence of smoking is reduced.

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