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Submitted: 25 November 2015 Modified: 16 May 2017
HERDIN Record #: PCHRD15112505355966

Association of coronary flow reserve by dipyridamole technetium-99m sestamibi single photon emission computed tomography with perfusion findings and risk factors for coronary artery disease.

Deverly D. Tumapon,
Jerry M. Obaldo

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BACKGROUND: Blunting of coronary flow reserve (CFR) may precede overt ischemia. The study aimed to correlate CFR with perfusion findings and risk factors for coronary artery disease (CAD).
METHODS: Fifty-four consecutive patients underwent dipyridamole-rest technetium-99m sestamibi single photon emission computed tomography (SPECT) on two separate days. CFR was computed as the quotient of myocardial blood flow (MBF= global tissue perfusion divided by arterial input function) at stress and at rest.
RESULTS: CFR was significantly lower in patients with abnormal perfusion vs normals (p=0.005). Reduced CFR was noted in 83% of patients with normal SPECT. Lower CFR was seen in hypertensive patients with left ventricular hypertrophy (LVH) compared to those without LVH (p=0.029); likewise in DM vs no DM (p=0.121). Independent predictors of reduced CFR were age and extent of ischemia.
CONCLUSION: Abnormal perfusion is associated with reduced CFR. In those with normal perfusion, there is a high prevalence of reduced CFR, which may be attributed to the presence of risk factors for CAD and LVH.

Publication Type
Journal
Publication Sub Type
Clinical trials/Clinical investigations (RCT's)
Title
The Philippine Journal of Nuclear Medicine
Frequency
Semi-Annual
Publication Date
January-June 2015
Volume
10
Issue
1
Page(s)
8-14
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box no. 21 Fulltext Print Format (Request Document)

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