The purpose of this study is to compare the pick up rate as well as the metastatic rate of the traditional method versus the clearance method using the lymph node revealing solution in resected breast cancer specimen and if the solution can affect the stage of breast carcinoma as well as the histologic architecture of the tissue.
MATERIALS AND METHODS:
This was a prospective experimental study conducted at Jose R. Reyes Memorial Medical Center from January 2000 to May 2001. All diagnosed cases of breast carcinoma confirmed by histopathologic examination either by fine needle aspiration biopsy, excision or incision biopsy who underwent modified radical mastectomy were included in this study. All patients were staged before and after the use of the lymph node revealing solution using the TNM staging.
A total of 37 female patients were included in this study with a mean age of 47.92 (range 26-65). Majority of the breast carcinoma belongs to stage III-A (43.2%) and Stage III-B (29.7%).
There was a significant increase in the number of lymph nodes harvested. An average of additional 4 lymph nodes were added to the lymph node harvest per specimen. It also changed the pathologic stage in 11 out of 37 patients (29%). The use of LNRS solution is a fast, time saving procedure which significantly increased the number of axillary lymph nodes detected. We propose the use of LNRS in routine pathologic work-up of patients with breast carcinoma.