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Submitted: 29 January 2013 Modified: 30 January 2013
HERDIN Record #: PCHRD13012914125490

Dextran 70 after large volume paracentecis in cirrhotic patients witn tense ascites.

R R. Gonzales,
V O. Tongco,
H D. Mappala,
J D. Sollano Jr

Seventeen cirrhotic patients with tense ascites were included in a prospective study to evaluate the clinical and biochemical changes after large volume paracentecis (LVP) with adjuvant Dextran 70 infusion. Six liters of ascitic fluid were removed in 10 males and 7 females followed immediately by infusion of Dextran 70 (150 ml/liter ascitic fluid removed) and the clinical (weight, abdominal circumference, pulse rate, respiratory rate, urine flow, mean arterial pressure and Kamofsky score) as well as biochemical profile (BUN, creatinine, serum Na, Serum K, and albumin) were monitored (baseline, days 1,3 and 6). One way analysis of variance (ANOVA) revealed significant differences in pulse rate, respiratory rate, and Karnofsky score with p values at 0.016,0.028 and 0.004 respectively. No significant differences were seen in the biochemical profile monitored. Complications during the study period were renal impairment, hyponatremia and hyperkalemia (3 cases each). Two patients died, one due to hepatic encephalopathy while the other due to GI bleeding. In conclusion, LVP with adjuvant Dextran 70 infusion is a safe, effective and inexpensive treatment of cirrhotic patients with tense ascites.

Publication Type
Biennial Report
University of Santo Tomas Research Report 1994-1996
Publication Date
January 1996

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