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Submitted: 13 September 2012 Modified: 30 May 2013
HERDIN Record #: NCR-RITM-12091310102364

Lack of Efficacy of High-Dose Intravenous Immunoglobulin Treatment of Severe Thrombocytopenia in Patients with Secondary Dengue Virus Infection

1Efren M. Dimaano,
2Mariko Saito,
3Shoko Honda,
5Maria T. Alonzo,
7Cynthia A. Mapua,
8Shingo Inoue,
9Atsushi Kumaori,
10Ronald R. Matias,
11Filipinas F. Natividad,
12Kazunori Oishi
Department of Internal Medicine and Virology - Institute of tropical Medicine Nagasaki University,
Department of Disaster Prevention System/Faculty of Risk and Crisis Management - Chiba Institute of Science,
Laboratory for Clinical Research on Infectious Diseases - Osaka University,
International Research Center for Infectious Diseases - Osaka University,
Research Institute for Microbial Diseases - Osaka University,
Department of Blood Borne Diseases - San Lazaro Hospital,
Research and Biotechnology Division - St. Luke's Medical Center


Because most cases of secondary dengue virus infection are associated with an increased level of plateletassociated IgG, a high dose of intravenous immunoglobulin (IVIG) may have an effect on the development of severe thrombocytopenia in this disease. A randomized, controlled study was conducted with two treatment groups consisting of a treatment (IVIG) group (n  15) and a non-treatment (non-IVIG) group (n  16) to determine whether a high dose of IVIG is effective in hastening the recovery from thrombocytopenia in patients with secondary dengue virus infection. No significant difference was found in the baseline demographic data between the two groups. No adverse effect of IVIG was observed, but no effect in hastening the recovery of platelet counts was found in patients with secondary dengue infections. The lack of efficacy of IVIG suggests that platelet clearance by macrophages through Fc receptors is not a primary mechanism in this disease

Publication Type:
Publication Sub Type:
Journal Article, Original
St. Luke's Journal of Medicine
Publication Date:
St. Luke's Medical Center

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