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Submitted: 22 February 2011 Modified: 03 November 2017
HERDIN Record #: PCHRD02221109020890

Risk factors associated with malignant endometrial lesions in postmenopausal women presenting with abnormal uterine bleeding: A retrospective review.

1Irene L. Uy,
2Ma.Asuncion Fernandez,
3Brenda Bernadette P. Bautista-Zamora
Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology - St. Luke's Medical Center

Abstract

OBJECTIVES: To identify clinical, sonographic and hysteroscopic characteristics associated with malignant endometrial lesions.


METHODS: This is a retrospective descriptive study that included all menopausal women presenting with vaginal bleeding in a tertiary care hospital from January 2007 to June 2010. Clinical, sonographic and hysteroscopic findings were evaluated as predictor variables for development of endometrial adenocarcinoma.


RESULTS: Thirteen out of the 215 patients had endometrioid adenocarcinoma, in women presenting with postmenopausal bleeding, with a prevalence rate of 6%. A trend towards harm is seen among the following factors: age of > 60 years (OR 1.19; 95% CI, 0.29-4.46), menarche < 12 years (OR 1.07; 95% CI, 0.22-4.66), endometrial stripe >/- 10mm (OR 2.02; 95% CI, 0.58-7.09), lesion of diameter < 1cm (OR 1.57; 95% CI, 0.45-5.74), presence of cystic space (OR 4.28; 95% CI, 1.00-17.36), and soft consistency (OR 1.94; 95% CI, 0.47-9.21).


CONCLUSION: Increasing age, early onset of menarche, endometrial thickness of >/- 10mm, hysteroscopic characteristics (lesion diameter of less than 1 em, presence of cystic space and soft consistency) increases the probability of carcinoma.

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency:
Annual
Publication Date:
January-December 2010
Volume:
7
Page(s):
1-6
Publisher:
Philippine Society of Reproductive Endocrinology and Infertility, Inc.

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 2 Fulltext Print Format (Request Document)
Philippine Council for Health Research and Development Library Box No. 2 Fulltext pdf (Request Document)
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