Glandular cardiac myxoma: A histochemical case study of the glandular epithelium and review of literature .

Background ÃÆ'Æ'Æ’ÃÆ'†â€™ÃÆ'Æ'â€Ã...¡ÃÆ'‚¢ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â‚¬Ã...¡ÃÆ'‚¬ÃÆ'Æ'Æ’ÃÆ'¢â‚¬Ã...¡ÃÆ'Æ'¢ÃÆ'¢â€Ã...¡Ã‚¬ÃÆ'‚ A glandular component in cardiac myxoma is uncommon. We described a case of a glandular cardiac myxoma removed from the right atrium in a 43 year old woman. Histopathologic evaluation revealed a typical cardiac myxoma with classic stellate cells disposed singly while some displaying cellular syncytia set in a loose myxoid matrix admixed with several benign mucin-producing glandular luminal structures. The glandular cells demonstrated strong histochemical reactivity with Periodic Acid-Schiff with diastase, mucicarmine, alcian blue at pH 2.5 and colloidal iron which revealed presence of acidic, simple, non-sulfated, sialic, epithelial type of mucin within the tumor. The presence of these glandular structures within a cardiac myxoma unless recognized as part of the tumor may lead to the difficulty and erroneous interpretation of a metastatic mucinous adenocarcinoma, thus, familiarization with this histo-logic variant coupled with special stains and careful clinical history, can help provide a correct interpretation of this lesion. (Author)