Background. Colorectal Cancer is among the leading causes of cancer-related morbidity and mortality in our society today. Carcinoembryonic antigen is considered as a factor predictive of survival and recurrence in colorectal cancer patients. This study is useful in determining whether preoperative CEA levels among Filipinos is a valuable predictor of survival and recurrence of Colorectal Cancer.
Methodology. A retrospective review of the records of 442 patients with colorectal cancer included in the Colorectal Database of the St. Luke's Medical Center, Research and Biotechnology Division was done. These included patients from September 1998 to January 2005.
Results. There was a significant association between preoperative CEA level and tumor stage (p=0.038). The median survival for all patients with preoperative CEA <5 and >5 ng/ml were 68 and 72 respectively (p=0.007). In the univariate cox regression analysis, CEA (p=0.008), sex (p=0.034) and stage (p=0.001) were found to be significant prognostic factors.
Conclusions. By multivariate analysis, it showed that stage of disease and preoperative CEA level were the two most significant prognostic factor. In this study elevated preoperative CEA levels in patients with colorectal cancer is correlated to a lower survival rate and a more advanced stage of the disease but there was no statistical significance in the correlation of preoperative CEA level and recurrence of the disease. (Author)
In this study we aim to evaluate the prognostic significance of preoperative CEA levels of patients with colorectal cancer treated in St. Luke's Medical Center. Aside from evaluating the correlation of preoperative CEA levels with the survival and recurrence of disease among patients with colorectal cancer, we aim to correlate preoperative CEA levels with the stage of disease and cancer differentiation.