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Submitted: 08 February 2008 Modified: 07 September 2012
HERDIN Record #: PCHRD020808010222

Comparison of three protocols for Controlled Ovarian Hyperstimulation (COH) for clomiphene citrate poor responders.

1Maria Lourdes Zosas-Cabling,
2Ma. Concepcion Ilao-Oreta
Department of Obstetrics and Gynecology - St. Luke's Medical Center

Abstract

Objective:
To compare the efficacy of Letrozole and Gonadotropin, given alone or in combination, in controlled ovarian hyperstimulation in Clomiphene citrate poor responders.

Study Design:
Prospective, non-randomized observational study on Clomiphene citrate poor responders at the St. Luke's Medical Center setting from January to July 2006.

Results:
Letrozole and gonadotropins, whether given alone or in combination, have similar clinical outcomes in terms of endometrial thickness during ovulation and the number of dominant follicles developed. The use of gonadotropins results in 100% ovulation rate, similar to results when Letrozole is used as an adjunct. Letrozole significantly reduces the dose of gonadotropin required to develop a mature follicle.

Conclusion:
Since the use of Letrozole and gonadotropins for ovarian hyperstimulation had similar results, Letrozole has the advantage of reduced cost and greater patient acceptance. It may be used alone or in conjunction with gonadotropins for poor responders to Clomiphene citrate.

1.
Publication Type:
Journal
Publication Sub Type:
Journal Article, Original
Title:
Philippine Journal of Reproductive Endocrinology and Infertility
Frequency:
Semi-Annual
Publication Date:
January-June 2007
Volume:
4
Issue:
1
Page(s):
7-12
Publisher:
Philippine Society of Reproductive Endocrinology and Infertility, Inc.

Objectives

To compare the efficacy of Letrozole and Gonadotropin, given alone or in combination, in controlled ovarian hyperstimulation in Clomiphene citrate poor responders.

LocationCall NumberAvailable FormatAvailability
Philippine Council for Health Research and Development Library Box No. 2 Fulltext Print Format (Request Document)
Philippine Council for Health Research and Development Library Box No. 2 Fulltext pdf (Request Document)
1. Mitwally, M , Casper, R . "Aromatase inhibition improves ovarian response to follicle-stimulation hormone in poor responders" Fertil Steril 77, 776-780, 2002 - [External Link]
2. AL Fosan, H , Al-Khaduri, M , Tan, SL , Tulandi, T . "A randomized trial of Letrozle versus Clomiphene citrate in women undergoing superovulation" Fertil Steril 82, 1561-1563, 2004 - [External Link]
3. Mitwally, M , Casper, R . "Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation" J Soc Gynecol Invest 11, 406-415, 2004 - [External Link]