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Submitted: 20 September 2007 Modified: 18 September 2017
HERDIN Record #: PCHRD091907050931

Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines.

1Tsuyoshi Nagatake,
2Kazunori Oishi,
3Maria T. Cinco,
4Cynthia A. Mapua,
5Shingo Inoue,
6Deu John M. Cruz,
7Mary Ann N. Pancho,
8Carol Z. Tanig,
9Ronald R. Matias,
10Kouichi Morita,
11Filipinas F. Natividad,
12Akira Igarashi,
13Celia C. Carlos
Nagasaki University, Japan,


To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St. Luke's Medical Center in Quezon City, between 1999 and 2001 in Metro Manila, and adjoining provinces the Philippines, with a laboratory-confirmed dengue virus infection were evaluated. One third of the patients had DHF, and most of these patients were without shock. Restlessness, epistaxis, and abdominal pain were more associated with DHF. The platelet count was significantly lower in the DHF group than in the DF group before and after defervescence. In the DHF patients, the hematocrit was significantly increased before defervescence, and decreased the day after due to administration of intravenous fluid. Coagulation abnormalities associated with most DHF patients were thrombocytopenia and an increased iibrinolysis, but not disseminated intravascular coagulation. We present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and consequently earlier appropriate treatment of dengue virus infections. (Author)

Publication Type:
Publication Sub Type:
Journal Article, Original
St. Luke's Journal of Medicine
Publication Date:
January-June 2010
St. Luke's Medical Center

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Philippine Council for Health Research and Development Library Box No. 35 Fulltext pdf (Request Document)