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Submitted: 20 September 2007 Modified: 19 January 2017
HERDIN Record #: PCHRD091907110922

Phenomenology of "lubag" or X-linked dystonia-parkinsonism.

1Andrew Singleton,
2Joven Cuanang,
3Joel Advincula,
4Katrina Gwinn-Hardy,
5Paul Pasco,
6Dena Hernandez,
7Filipinas F. Natividad,
8Virgilio Gerald H. Evidente,
9Amado San Luis,
10Raymund Esteban,
11John Hardy,
12Jhoe Anthony Alfon
National Institutes of Health, Baltimore, Md,
U.E.R.M. Memorial Medical Center,
Philippine General Hospital,
West Visayas State University,
Mayo Clinic, Scottsdale, Arizona, USA

Abstract

X-linked dystonia-parkinsonism (XDP), or Lubag syndrome, is known to cause progressive dystonia, with or without parkinsonism, among Filipino male adults with maternal roots from the Philippine island of Panay. We present cinematographic material of 11 cases of Lubag carrying the XDP haplotypes who manifest with a wide spectrum of movement disorders, including dystonia, tremor, parkinsonism, myoclonus, chorea, and myorhythmia. Because of overlapping features, Lubag patients are commonly misdiagnosed as idiopathic dystonia, essential tremor, Parkinson's disease, or Parkinson's-plus syndromes. Thus, it is imperative to elicit an exhaustive family history in any Filipino male adult who presents with a movement disorder. (Author)

1.
Publication Type:
Journal
Publication Sub Type:
Others
Title:
Movement Disorders
Frequency:
Unknown
Publication Date:
June 2002
Volume:
17
Issue:
6
Page(s):
1271-1277
Publisher:
Movement Disorder Society

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