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Submitted: 16 August 2011
HERDIN Record #: PCHRD08161112080277

Innate and non-specific resistance to Schistosomiasis.

Remigio M. Olveda

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Initial investigations compared the degree of susceptibility to Schistosoma japonicum infection of mice (BALB/C) and outbred rats by a primary infection of cercariae and subsequent recovery of adult worms. The contributions of mononuclear phagocytes, specifically monocytes from humans and macrophages from mice and rats, to innate resistance using an in-vitro system were also compared.Monolayers from human peripheral blood mononuclear cells, monolayers from pooled peritoneal exudate cells of normal mice and macrophages from individual outbred rats were found to induce significant schistosomula killing.

Publication Type
Research Project
November 30, 1991