Due to the growing incidence of cancer in the Philippines, production of a new anticancer compounds is needed. It has been found that marine invertebrate organisms like sponges are good sources of anticancer compounds. Examples of these are cyclic peptides which have been shown by in vitro assays to have high levels of bioactivity. However, a large amount of sponge would be needed to produce significant quantities of the compound to conduct in vivo assays. Thus, chemical synthesis of microcionamide, a cyclooctapeptide. Synthesis of the compound relied heavily on the use of carbodiimides like EDAC to mediate amide bond formation between amino acids. In this presentation, we wish to disclose some of the results obtained for the preparation of the cyclooctapeptide.