Report an error   

Submitted: 04 November 2010 Modified: 17 November 2010
HERDIN Record #: PCHRD11031003115463

Glucose-6-phosphate dehydrogenase deficiency in malaria endemic areas in the Philippines.

Andres S. Cubacub,
Marietta C. Baccay,
Adoracion Z. Reyes,
Fermin A. Talao,
Nelia P. Salazar,
Crispin P. Echiverri,
Myrna R. Acacio,

See More

Glucose-6-phosphate dehydrogenase (G-6-PD) deficiency, a hereditary biochemical defect of erythrocytes, was detected among residents of malaria endemic areas on the big island of Luzon, Republic of the Philippines. A total of 774 individuals were examined, 1.5 to 68 years old consisting of 485 males and 289 females. The overall prevalence rate of 5.5% among Filipinos concurred with data from previous studies. Pedigrees of selected families showed a Mendelian pattern of inheritance. The potential hazard of treating G-6-PD deficient patients with antimalarials such as primaquine, sulfonamide, sulfones, quinidine, and quinine, or combination thereof, is recognized.

Publication Type
Research Report
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library Abstract Print Format (Request Document)
1. Clyde, D F, Allison, A C. "Malaria in African children with deficient G-P-D in erythrocytes" British Medical Journal , 320-322, 0001
2. Weniger, H . "Toxicity and side effects of primaquine and the 8-aminoquinolines" WHO/MAL/79.905 ,
3. Allison, A C. "Glucose-6-phosphate dehydrogenase deficiency in red blood cells of East Africans" Nature (186): 531-532, 1960
4. Paraan, A A , Blackwell, R Q, Huang, JT H, Yen, L , Chien, L C. "Incidence of G-6-PD and hemoglobin H among Filipinos" Vox Sanguinis 15, 65-69, 1968
5. Harinasuta, T , Bunnag, D . "Drug resistant malaria with special reference to chemotherapy" Mosquito Borne Diseases Bulletin (1): 23-30, 1984
6. H, Cross J, Uylangco, C V, Alcantara, A R. "Preliminary studies of patients with malaria and glucose-6-phosphate dehydrogenase deficiency, and observations on chloroquine resistance Plasmodium falciparum infections" Philippine Journal of Microbiology and Infectious Diseases (9): 95-104, 1980
7. World Health Organiz, . "Standardization of procedures for the study of glucose-6-phosphate dehydrogenase" Technical Reprint Series (338): 5-51, 1967
8. Wernsdorfer, W H, Bruce-Chwatt, L J, Peters, W , Black, R H, Canfield, C J, Clyde, D F. "Chemotherapy of malaria 2nd ed" , 1981
9. Jongco, A P, Chan, A C, Santos-Ocampo, P D, Mendoza, R . "Erythrocyte glucose-6-phosphate dehydrogenase deficiency in Filipinos" Philippine Journal of Pediatrics 7, 153-170, 1968
10. Uylangco, C V, Cross, J H, Alcantara, A K, Buck, R L. "Malaria at San Lazaro Hospital, Manila, Philippines, 1979-1981" American Journal of Tropical Medicine and Hygiene (32): 212-216, 1982
11. Bayani-Sioson, P S. "Some biochemical polymorhic traits (Filipino population) 2. glucose-6-phosphate dehydrogenase deficiency and electrophoretic variants" Acta Medica Phillipina (5): 156-163, 1969
12. Goldstein, J L, Brown, M S. "Genetic aspects of human disease" Harrison , 313-329, 1977
13. Pearlman, E J, Phintuyothin, P , Samransamruajkit, S , Laixuthai, B , Lampe, R M, Miller, C F, Karnchanachetanee, C , Doberstyn, E B, Hall, A P. "Sequential treatment with quinine and mefloquine or quinine and pyrimethamine - sulfadoxine for falciparum malaria" British Medical Journal 1, 1626-1628, 1977
14. Warrell, D A, Doberstyn, E B, Dixon, K E, Harinasuta, T . "Recent advances in malaria with special reference to Southeast Asia" Southeast Asian Journal of Tropical Medicine and Public Health (13): 1-34, 1982
15. Pungpartk, S , Subchareon, A , Chongsuphajaisiddhi, T . "Treatment of falciparum malaria in Thai children" Southeast Asian Journal of Tropical Medicine and Public Health (10): 132-137, 1979
16. Fairbanks, V F, Fernandez, M N. "Glucose-6-phosphate dehydrogenase in the Philippines: report of a new variant G-6-PD Panay" Mayo Clinic Proceedings (43): 645-660, 1968
17. Hess, U . "A proposal for more effective control of chloroquine resistant falciparum malaria" 10th International Congress on Tropical Medicine and Malaria, Manila, Philippines , 279-280, 1980
18. Khoo, K . "The treatment of malaria in glucose-6-phosphate dehydrogenase deficient patients in Sabah" Annals of Tropical Medicine and Parasitology (75): 591-595, 1981
19. Kidson, C , Gorman, J G. "A challenge to the concept of selection by malaria in glucose-6-phosphate dehydrogenase deficiency" Nature (196): 489-51, 1962
20. Horecker, B L, Kornberg, A . "Glucose-6-phosphate dehydrogenase" Methods in Enzymology, Colowick, S.P. & Kaplan N.O. (eds) 1, 323, 1955
21. Waller, H D, Lohr, G W. "Glucose-6-phosphate dehyfrogenase" Method of Enzymatic Analysis, Bergemeyer, H.U. (ed,) New York, Academic Press , 636, 1974
22. Brewer, G J, Knutzen, C A. "The micro methemoglobin-reduction test for glucose-6-phosphate dehydrogenase deficiency" American Journal of Clinical Pathology (45): 82-84, 1966
23. Mashaal, H . "Clinical malariology" Tokyo: Southeast Asian Medical Information Center, International Medical Foundation of Japan , 1986
24. Frase, G R, Motulsky, A G, Stransky, E . "Glucose-6-phosphate dehydrogenase deficiency thallasemia and abnormal hemoglobin in the Philippines" Journal of Medical Genetics (1): 102-106, 1964
25. Nelson, D . "Basic methodology" Clinical Diagnosis and Management, Henry, J (ed.), 16th ed , 865,
26. Dobzhansky, T H, Sinnott, E W, Dunn, L C. "Principles of genetics 4th ed" McGraw-Hill Book Company , 31-57,
27. Smrkovski, L L, Buck, R L, Uylangco, C V, Rodriguez, C S, Alcantara, A K. "Studies of resistance to chloroquine, quinine, amodiaquine and mefloquine among Philippine strains of plasmodium falciparum" Transactions of the Royal Society of Tropical Medicine and Hygiene , 37-41, 1985
28. Deane, M , Esan, G , Okoye, V C, Miller, L H, Alling, D , Martin, S K. "Severe malaria and glucose-6-phosphate dehydrogenase deficiency: a reappraisal of the malaria/G-6-PD hypothesis" Lancet 1, 524-526, 1979
29. Warrell, D A, Phillips, R E, White, N J, Karbwang, J , Looareesuwan, S . "Intravenous quinidine for the treatment of severe falciparum malaria, clinical and pharmacokinetic studies" The New England Journal (312): 1273-1278, 1985
30. Motulsky, A G, Latte, B , Bernini, L , Siniscalco, M . "Favism and thallasemia in Sardinia and their relationship to malaria" Nature (190): 1179-1180, 1961
31. Nelson, D . "Erythrocytic disorders" Clinical Diagnosis and Management, Henry, J (ed.), 16th ed , 225,
32. Wernsdorfer, W . "Drug-resistant malaria" UNDP/WORLD BANK/ WHO Special Programme for Research and Training in Tropical Diseases , 1982
33. Wernsdorfer, W H, Kouznetsov, R L. "Drug resistant malaria - occurrence, control and surveillance" Bulletin of the World Health Organization (58): 341-352, 1980
34. Motulsky, A G. "Metabolic polymorphisms and the role of infectious disease in human evolution" Human Biology (32): 28-62, 1960
35. Punzal, P A, de la Paz, A , Villatuya, N L. "Correlations of malaria and splenomegaly among Dumagats" Philippine Journal of Internal Medicine (23): 99-105, 1985
36. Nagel, R L, Rinaldi, A , Raventos-Suarez, C , Roth, E F. "Glucose-6-phosphate dehydrogenase deficiency inhibits in vitro growth of Plasmodium falciparum" Proceedings of the National Academy of Science, USA (80): 298-299, 1983