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Submitted: 29 April 2019 Modified: 29 April 2019
HERDIN Record #: 100731-19042909332077

Effectiveness of spironolactone as add-on therapy in resistant hypertension: A meta analysis of randomized controlled trials.

Katherine N. Requinta,
Jessielyn E. Sia,
Arvin R. Yumul

Background: Resistant hypertension is a common clinical problem that both primary care clinicians and specialists encounter worldwide. The 7ili joint national national committee (JNC 7) defined resistant hypertension as inability to achieve a blood pressure lower than 140/90 mm Hg despite optimal doses of 3 or more antihypertensive drugs, including 1 diuretic.

Methods: Literarture search was done through PubMed and Cochrane using the search terms spironolactone, resistant hypertension, and randomized controlled trial. This study included 4 randomized controlled trials.

Results: There was a total number of 439 patients in the spironolactone group and 430 participants in the placebo group. In the spironolactone group there was a statistically significant reduction in systolic blood pressure compared to the placebo group at the end of treatment period, with a mean difference of -13.75 (-18.96, -8.53), p<O.OOOOl.The same observation was seen comparing the diastolic blood pressure between the spironolactone and placebo groups, where the mean difference was -5.71 (-9.36, -2.07), p<O.002, in favor of spironolactone.

Conclusion: Spironolactone as an add-on therapy drug for resistant hypertension effectively red es ) both systolic and diastolic blood pressure.

Publication Type
Research Report
January 1-December 31, 2015
LocationLocation CodeAvailable FormatAvailability
Philippine Heart Center Medical Library MA.001.15 Fulltext Print Format