Background: Bronchiectasis can have important hemodynamic consequences because of proliferation of the bronchial circulation in its vicinity. Airflow obstruction is the functional hallmark anatomical site of obstruction would provide pathologic insights and might allow greater therapeutic precision, as well as improving the accuracy with which the effects of intervention are monitored of bronchiectasis (1). The aim of the present study is to assess the
impact of the different types of bronchiectasis on clinical features and pulmonary function tests. The study also aimed determine the correlation between pulmonary function and HRCT score among patients with bronchiectasis.
Method: All Bronchiectatic patients with HRCT scans referred for pulmonary function test (PFT) at Philippine Heart Center Pulmonary Laboratory and those in an outpatient diagnosed with Bronchiectasis and with PFT who met the selection criteria were included in the study. This is a 5 year review of records, PFT's and images from March 2013 to July 2018. Comparisons of the anthropometry, clinical data, high-resolution CT, and pulmonary function tests according to the different types of bronchiectasis were examined using the analysis of variance (ANOVA). Pearson correlation coefficient was calculated to investigate the association between pulmonary function and HRCT score. Statistical significance was established as P <0.05.
Results: Of the 81 patients included in the study, 42 patients (52%) were men and 39 patients (48%) were women. There is a statistically significant difference between the three groups in relation to the mean values of FVC%, FEV1% (P < 0.0001), FEV1/FVC% (0.03). Mean values were more significantly reduced in saccular (cystic) bronchiectasis group. Global HRCT scores for all patients with bronchiectasis has a strong statistically significant, negatively correlated with the values of FEV1% (P <0.001).
Conclusion: In conclusion, cystic bronchiectasis is associated with more severe lung function impairment and worse HRCT scores as compared with cylindrical and varicose type bronchiectasis. HRCT scores correlate with FEV1% and could be a predictor of airflow obstruction. The vicious cycle of chronic infection and damage to the airways leads to increasingly severe symptoms, physiological impairment manifesting as ventilatory defects and abnormalities in gas exchange.