This study determined the predictors of clients' adherence to Public - Private Mix DOTS treatment. Grounded on Pender's Health Promotion Model, the study employed a descriptive correlational research among 70 adherent and non-adherent clients of Mandaue PPMD Unit-South District. The Anti-Tuberculosis Chemotherapy Adherence Index was utilized to derive data and was processed using Statistical Package for Social Sciences (SPSS) version 16. A discriminant analysis was conducted to predict whether a client was adherent or not. Predictor variables tested were age, educational attainment, income, sputum smear status, accessibility, co-morbidity, perceived self-efficacy, quality of health services, perceived social support, perceived social stigma, motivation, side-effects and adverse reactions to treatment. Significant mean differences were observed among three variables, namely quality of health services (p=0.007), income (p=0.030) and perceived social stigma (p=0.032). The discriminate function revealed a significant association between groups and all predictors, accounting for 71.4% of between group variability, although closer analysis of the structure matrix revealed only three significant predictors, namely quality of health services (0.476), income (-0.381) and perceived social stigma (-0.376) with accessibility and perceived self-efficacy as poor predictors. The cross validated classification showed that overall 61.4% were correctly classified. Quality of health services, income and perceived social stigma have a bearing on adherence to PPMD treatment. Income and perceived social stigma are good screening parameters in assessing clients' adherence. Quality of health services should be considered when providing treatment since it is a good determinant of clients' likelihood of treatment adherence. Thus, the researcher recommends that NTP managers need to develop an evaluation tool that the clients can use to evaluate provision of health services and be submitted for monitoring, the staff needs to assess intensively the client's income level, and perceived social stigma prior to initiation and while on treatment. Frequent counseling need to be provided to clients with high perception to social stigma and assistance should be readily available to those with low income and have poor social support system. Future researchers may conduct a similar study in a larger population with more detailed items in the significant variables.