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Submitted: 21 February 2019 Modified: 28 February 2019
HERDIN Record #: 7078-19022114251862

In vitro angiotensin converting enzyme inhibition activity of Mahogany, Swietenia mahogani (L. Jacq. 1760) leaf extract.

Franchezka Kayerielle  A. Gamboa,
Lord Pol  B. Liston

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The study examines the percent ACE inhibition of Swietenia mahogani ethanol extract through the ACE inhibitory assay by (Cushman and Cheung 1971) with a slight modification by Saputri et al.,(2015). The ethanol leaf extract Swietenia mahogani elicited angiotensin converting enzyme inhibition activity based on the significant ACE inhibition of test solutions, 25 mcg/mL yielding 60±0.79%, 50 mcg/mL with 66±0.82% and 100 mcg/mL with 72±0.52%, respectively. The results showed that as the concentration of the test solutions increases percent ACE inhibition also increased revealing a dose-dependent ACE inhibitory activity. The median inhibitory concentration (IC50) was at 0.52 mcg/mL implying that only half a microgram is needed to elicit 50% ACE inhibition activity.....

Publication Type
Thesis/Dissertations
Thesis Degree
BS
Specialization
Pharmacy
Publication Date
March 2018
LocationLocation CodeAvailable FormatAvailability
University of San Carlos-Josef Baumgartner Learning Resource Center, Science and Technology Section T / G144 Fulltext Print Format (Ask the Information Officer)
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