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Submitted: 09 December 2015 Modified: 09 December 2015
HERDIN Record #: CAR-UCBCF-15120901002329

Anti-inflammatory activities of the aqueous extract of the stem of Tinospora crispa (family Menispermaceae).

Maria Faye Nenette Cariaga,
Regina Lourdes Hipol,
Roland Hipol

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Tinospora crispa of the family Menispermaceae is a popular folk
medicine in the Cordillera for the treatment of common pains such as
arthritis, rheumatism and sprains. The aim of this study was to evaluate
the anti-inflammatory properties of the aqueous extract of the dried
stem of the plant in order to provide scientific grounding to its use.
Acute inflammation was induced in rat models by introducing
carageenan in hind paws causing edema. The extract, at all
concentrations (50 mg/kg, 100 mg/kg and 150 mg/kg), significantly
inhibited swelling of the paw. In vitro anti-inflammatory assays were
also conducted. Tinospora crispa was found to cause stabilization of
cellular membranes at 5% w/v and 7.5% w/v concentrations and
inhibition of protein denaturation. These activities are therefore
suggested as the possible mechanisms for the anti-inflammatory

action of Tinospora crispa.


Publication Type
Others
Place of Publication
Journal of Nature Studies
Publication Date
2012

Objectives



















The aim of this study was to evaluate
the anti-inflammatory properties of the aqueous extract of the dried
stem of the plant in order to provide scientific grounding to its use.
Acute inflammation was induced in rat models by introducing
carageenan in hind paws causing edema.