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Submitted: 16 March 2015 Modified: 22 August 2019
HERDIN Record #: NCR-UERMMMC-1503160504521

The effect of oral vitamin C supplementation on the blood pressure levels of hypertensive adults in Barangay Doña Imelda: a randomized controlled study.

Sir Lawrence Go,
Phillip Sebastian Golez,
Claudine Rosary Gomez,
Aileen Zita Gopez,
Kristine Nikita Gonzales,
Kristina Carla Grant,
Pocholo Guadalupe,
Nikaelle Guevara,
Ma Louiji Guillermo,
Melissa Therese Guillermo,
Abigail Mayled Laus,
Marvie Liban,
Joe Mhel Libardo,
Franco Lim,
Leopoldo P. Sison Jr.

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Introduction The study aimed to determine the effect of 1000 mg vitamin C supplementation on the systolic and diastolic pressure of hypertensive subject taking oral anti-hypertensive agents.

Methods Thirty-two previously diagnosed hypertensive patients maintained on medication were randomly assigned to receive oral vitamin C 1000 mg daily or a dummy drug for four weeks. Post treatment systolic and diastolic blood pressures were compared with baseline measurements within groups. The mean difference in the systolic and diastolic blood pressure between the vitamin C and control groups were compared.

Results  There was a significant decrease in the mean systolic pressure (26.4 mm Hg) and diastolic pressure (7.6 mm Hg) in the vitamin C group. A significant decrease was seen in the mean systolic pressure (12.6 mm Hg) but not in the diastolic pressure (4.3 mm Hg) of the control group. A comparison between groups did not show a significant difference in the mean decrease of both systolic pressure (13.8 mmHg, p = 0.29) and diastolic pressure (3.25 mmHg, p = 0.16).

Conclusion The investigators conclude that four weeks of daily supplementation of 1000 mg vitamin C did not cause any significant decrease in the systolic and diastolic blood pressure of hypertensive subjects as compared to placebo. Further studies need to be conducted for higher doses considered in the safe range of oral vitamin C used as an adjunct to pharmacological therapy

Publication Type
Publication Sub Type
Journal Article, Original
The Health Sciences Journal
Publication Date
July-December 2014
LocationLocation CodeAvailable FormatAvailability
UERMMMC Fulltext Print Format
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