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Submitted: 09 February 2015 Modified: 22 August 2019
HERDIN Record #: NCR-UERMMMC-15020906031038

Effect of zinc supplementation as an adjunct in the treatment of pneumonia in children: a meta-analysis.

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Introduction This meta-analysis was done to evaluate the efficacy of zinc supplementation as adjunct to antibiotics in decreasing the duration of resolution of tachypnea, time to recovery, and length of hospital stay of pneumonia in children 2 to 59 months.


Methods This was a meta-analysis of randomized, blinded, placebo-controlled intervention trials. The studies for inclusion were identified from several international and local search engine and journal hand search. Included studies were appraised for validity. Statistical analysis of the data was done using Review Manager Version 5.2. Summary mean difference and 95% confidence interval for each outcome variable were estimated using a random-effects model in the presence of significance heterogeneity. Tests for heterogeneity were computed using tau-square and chi-square.


Results There was no difference in children who received elemental zinc as adjunct to antibiotics in terms of decreasing the duration of resolution of tachypnea (P = 0.48, 955 CI - 13.76, 6.41), time to recovery (P = 0.11, 95% CI - 10.18, 1.00) and length of hospital stay (P = 0.05, 95% CI - 11.54, 0.04).


Conclusion This study showed that there was no significant evidence for the efficacy of zinc supplementation as an adjunct in the treatment of pneumonia in children despite including newer studies for analysis.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
The Health Sciences Journal
Frequency
Others
Publication Date
January-June 2014
Volume
3
Issue
1
Page(s)
36-42
LocationLocation CodeAvailable FormatAvailability
UERMMMC Fulltext Print Format
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