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Submitted: 05 February 2014 Modified: 13 June 2014
HERDIN Record #: R04A-DLSHSI-14020508332217

A FIVE YEAR REVIEW OF URINARY TRACT INFECTION AMONG ADULT PATIENTS CAUSED BY EXTENDED SPECTRUM BETA-LACTAMASE (ESBL) PRODUCING PATHOGENS AT A TERTIARY HOSPITAL IN CAVITE, PHILIPPINES

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Developing multi - drug resistance due to extended spectrum beta - lactamase (ESBL) production limits the use of beta lactam antibiotics against Escherichia coli and Klebsiella pneumoniae.

Objectives: To describe the clinical characteristics of adult patients admitted under the Department of Internal Medicine due to UTI caused by ESBL pathogens, its antibiotic resistance pattern and its clinical outcome.

Design: Cross sectional descriptive study

Setting: UTI patients caused by ESBL pathogens admitted under the Department of Internal Medicine in De La Salle University Medical Center from January 1, 2008 to December 31, 2012.

Patients: Fifty-six UTI patients with urine culture and sensitivity compatible with ESBL pathogens included in this study out of 193 patients with urine culture.

Results: Incidence of 29% (56/193) UTI caused by ESBL pathogens presented in the study. Majority of patients were women 60.71%, 14.29% were within 80 - 89 years old, youngest patient was 19 years old and oldest was 90 years old. Most common co-morbidity identified were diabetes mellitus 44.64%, cardiovascular disease 26.79%, chronic kidney disease 21.43%, urologic problem (Benign Prostatic Hyperplasia) 19.64% and 8.92% noted to have a malignancy (bladder, colonic, hepatocellular, ovarian, pancreatic). The most frequently identified etiology was Escherichia coli 50% and Klebsiella pneumoniae 22%. The antibiotic with highest resistance to ESBL pathogens in this study was Cefuroxime and no resistance was noted with Imipenem and Meropenem. Out of 56 patients, there were 46 sent home, 5 mortality, 5 transferred to other hospital and 1 home per request.

Objectives

Objectives: To describe the clinical characteristics of adult patients admitted under the Department of Internal Medicine due to UTI caused by ESBL pathogens, its antibiotic resistance pattern and its clinical outcome.

LocationLocation CodeAvailable FormatAvailability
3/F Room 6301 De La Salle Angelo King Medical Research Center Abstract Print Format