The aim of this study was to investigate the relationship between rainfall, temperature and humidity and the number of dengue fever cases admitted patients at Northern Mindanao Medical Center (NMMC) from 1998-2007. Dengue is a serious public health problem in the world. Increasing dengue fever cases have been linked to climate change; however, contradicting reports show inconclusive relationship between dengue and climatic factors. This study investigates amount of rainfall, temperature and relative humidity as climatic factors affecting dengue fever cases in admitted patients at Northern Mindanao Medical Center from 1998-2007. Monthly dengue fever cases and climatic data for Northern Mindanao were collected over a 10-year period (1998-2007). Climatic factors such as rainfall, temperature and relative humidity were linked with dengue fever cases through linear regression analysis. Weak positive correlation between dengue fever cases and amount of rainfall and temperature was established (r=0.177 and r=0.175 respectively). Weak negative correlation between dengue fever cases and relative humidity was established (r=0.017). However, no significant relationship between these climatic factors was established (p>0.05). Future studies using data of more than 10 years that will examine how these climatic factors may affect dengue morbidity, mortality and incidence rates are recommended.