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Submitted: 11 October 2012
HERDIN Record #: R04A-DLSHSI-12101111292895

Association of sensitization to aeroallergens and Allergic Respiratory Diseases (ARd) in children aged 2 to 18 years old in a tertiary hospital.

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Objective: To determine the association of skin test reactivity(STR) to the different aeroallergens tested with ARD.
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Design:Cross-sectional Analytic Study
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Subjects: Children 2 to18 y.o. with ARD
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Intervention: Skin prick test using 11 aeroallergens
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Outcome Measures: Chi-square: associations of aeroallergen STR with ARD; ARD with gender and FHx. ANOVA: associations of AI with ARD; age with ARD and AI. T-test: associations of gender and FHx with AI; AI with the severity of ARD.Linear regression: to rule out age, FHx as confounding factors to the association of AI with ARD.
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Results: Among 151 subjects, 26.4% have allergic rhinitis(AR), 45.7% have bronchial asthma(BA) and 22.7% have AR and BA. Sensitization to D.farinae, D.pteronyssinus, mold and cat dander (p0.017, 0.019, 0.010 and <0.001, respectively) was significantly associated with AR. D.farinae, cockroach, mold, cat dander and house dust was significantly associated with having BA and AR (p<0.0001, 0.026, <0.001, 0.040 and 0.017, respectively). BA common among the first 3 age groups while AR common among 13-18y.o.(p<0.001). FHx was significantly associated with ARD (p0.002). Mean AI significantly increased with age (p<0.001). There was a significant difference between FHx and mean AI (p<0.001) and between BA persistent and AI (p0.049). Linear regression showed that age and FHx were confounding variables to the association of mean AI and ARD (p<0.001 and 0.009, respectively).
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Conclusions: ARD had significant sensitization to D. farinae, D. pteronyssinus and
cockroach. There was a significant difference between FHx and mean AI and significant difference between BA persistent and AI. AI increased with age. Multivariate analysis showed age and FHx as confounders.

Objectives

To determine the association of skin test reactivity(STR) to the different aeroallergens tested with ARD.