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Submitted: 28 August 2012 Modified: 29 May 2013
HERDIN Record #: NCR-RITM-12082816131513

Comparison of clinical features and hematologic abnormalities between dengue fever and dengue hemorrhagic fever among children in the Philippines

Celia  C. Carlos,
Kazunori Oishi,
Cynthia A. Mapua,
Shingo Inoue,
Ronald R. Matias,
Kouichi Morita,
Filipinas F. Natividad,
Akira Igarashi,
Tsuyoshi Nagatake

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To demonstrate the differences of clinical features and hematologic abnormalities between dengue fever (DF) and dengue hemorrhagic fever (DHF), 359 pediatric patients admitted St. Luke's Medical Center in Quezon City, between 1999 and 2001 in Metro Manila, and adjoining provinces the Philippines, with a laboratory-confirmed dengue virus infection were evaluated. One third of the patients had DHF, and most of these patients were without shock. Restlessness, epistaxis, and abdominal pain were more associated with DHF. The platelet count was significantly lower in the DHF group than in the DF group before and after defervescence. In the DHF patients, the hematocrit was significantly increased before defervescence, and decreased the day after due to administration of intravenous fluid. Coagulation abnormalities associated with most DHF patients were thrombocytopenia and an increased fibrinolysis, but not disseminated intravascular coagulation. We present recent data on readily obtained clinical and laboratory data that can be used for early diagnosis and consequently earlier appropriate treatment of dengue virus infections.

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
The American Journal of Tropical Medicine and Hygiene
Frequency
Monthly
Publication Date
2005
Volume
73
Issue
2
Page(s)
435-440

Publication Type
Journal
Publication Sub Type
Journal Article, Original
Title
St Luke's Journal of Medicine
Frequency
Monthly
Publication Date
Volume
6
Issue
1
Page(s)
43-50
LocationLocation CodeAvailable FormatAvailability
RITM Fulltext Print Format
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