The study aimed to determine any antimicrobial activity of Musa sapientum (banana) peel extracts on Staphylococcus aureus, with levels of activity classified as very active, active, partially active and inactive. Vancomycin was used as the positive control of the study and plain NSS as negative control. The liquid supernatant of centrifuged banana peelings was impregnated into disks and antimicrobial activity was detected using Disk Diffusion method. Results showed a mean zone of inhibitionof 8mm for the banana peel impregnated disks. There were, however, 10 disks which showed zone of inhibitions measuring between 10mm - 12mm, indicating the presence of partial activity. Nevertheless, the mean zone of inhibition of 8mm implies that the banana peel extracts are inactive against Staphylococcus aureus. Significant difference was also established between the mean zones of inhibition between Vancomycin and Banana Peel Extracts indicating that the extracts is not an effective agent against Staphylococcus Aureus. Further recommendations include studies which utilize a different method of extraction and a histochemical analysis and biochemical isolation of the components of the banana peel that may have an antibacterial activity.