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Submitted: 12 September 2011 Modified: 16 May 2019
HERDIN Record #: PCHRD09121111091638

Frailty modeling of cardiovascular risk factors among Filipino.

Bridith S. Penaranda

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BACKGROUND: At present, majority of Filipino physicians are aware only of the Framingham list of CVD risk factors, and usually is the basis in identifying the Filipino patient's risk for heart disease accordingly. Some variances in the Filipino lifestyle and genetic profile may require some modifications on the existing risk equation.


OBJECTIVE: This aims to create a prediction model which can estimate CVD risk among Filipinos based on currently known risk factors using survival analysis.
Main objective: To derive a multivariate survival model for cardiovascular mortality among Filipino adults.
Specific objectives:
1. To derive a WEibull parametric model for cardiovascular mortality using age, gender, low density lipoprotein (LDL), high -density lipoprotein (HDL). blood pressure, diabetes and smoking as risk factors.
2. To determine if incorpoaration of a frailty component to the parametric regression model is necessary to account for the other unmeasured risk factors
3. If a frailty component is necessary, then compare the two frailty models namely, Gamma and Inverse Gaussian distribution.


METHODS: Six out of 13 national regions were included in the cohort. There were 1749 individuals included. Survival techniques specifically Weibull regression model and frailty model were fitted to the data.


RESULTS: The study found five risk factors -age, gender, blood pressure, DM, and smoking-significant in predicting death due to cardiovascular disease. The effect of HDL and LDL was not found statistically significant in the model development.


CONCLUSIONS: Younger female individuals with non-elevated blood pressure, non-diabetics and who do not smoke have a greater chance of survival. A sex-specific model using Weibull distribution was chosen to be the distribution of choice. Incorporating fraity was not needed in the data.

Publication Type
Thesis/Dissertations
Thesis Degree
MS
Specialization
Public Health
Publication Date
April 2011
LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library RC669 P46 2011 Abstract Print Format (Request Document)
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