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HERDIN Record #: PCHRDPC040241 Submitted: 16 May 2007 Modified: 02 August 2019

Lactose malabsorption among healthy Filipino children.

 Daag, Jedas,
 Sanchez, Imelda,
 Baclayon, Melvina T,
 Santos-Ocampo, Perla,
 Sio-Aguilar, Juliet ,
 Nolasco, Ma. Estela

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A total of 200 healthy children, aged 2 months to 12 years, were included in the study to investigate the current status of lactose intolerance among healthy Filipino children using the non-invasive lactose breath hydrogen test. After a period of fast of four to eight hours depending on the age of the subject, and following a low-fiber diet twenty-four hours prior to the investigation, each subject underwent the breath hydrogen test using a lactose load of 1 gm/kg not to exceed 25 gm. Breath samples collected through disposable Haldane-Priestley tubes in multiples of three at baseline and subsequently after lactose ingestion at 30, 60, 90, 120, 150 and 180 minutes were analyzed using a special gas chromatograph (QuinTron Model 121 MicroLyzer). Of the 200 subjects examined, 101 (50 percent) had a positive breath test using the criterion of a rise in breath hydrogen of at least 20 ppm from the baseline. The mean rise in breath hydrogen after lactose ingestion in these malabsorbers was 57.3 ppm. The incidence of lactose malabsorption strikingly increased from ages 3-4 years to 11-12 years, with the highest incidence in the ages 9-10 years at 86 percent. For ages 1-2 years, 23 percent of the subjects were lactose malabsorbers. There were no infants aged 2-11 months who were lactose malabsorbing based on the breath test. No symptoms of malabsorption were also observed in this age group. Of those children who were lactose malabsorbers, only 4 (2 percent) developed mild abdominal discomfort and diarrhea during and after the test. This study underscores the presence of lactose malabsorption among healthy children and such may relate to the clinical syndrome of late-onset lactase deficiency. (Author)

Publication Type
Publication Sub Type
The Philippine Journal of Pediatrics
Publication Date
October-December 2002
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