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Submitted: 17 August 2011 Modified: 07 January 2015
HERDIN Record #: PCHRD08171102082850

Garlic as anti-hypertensive agent for mild hypertension: A randomized, double blind crossover study.

Elfina Jaban-Marasigan,
Nelia P. Cortes-Maramba,
Dina De Leon

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A double -blind cross-over clinical trial was undertaken at the Philippine General Hospital Out-patient Department with the general objective of determining the efficacy and safety of 4 weeks low-dose garlic capsule (250 mg, BID) versus placebo among patients with mild hypertension with 2 weeks wash out period. Twenty evaluable patients (13 females and 7 males) completed the study with a mean age of 46+-6.1 years. The baseline mean systolic BP was 136+-10.8 mmHg and diastolic BP of 93.68+-46 mmHg. Twelve patients received garlic while 8 received placebo initially resulting in a mean decrease of 4.42 mmHg systolic and 4 mmHg diastolic under garlic therapy while those with placebo had SBP fall 6.4 mmHg and 6.37 mmHg DBP. After the cross-over, the garlic-treated showed lower mean SBP and DBP compared with placebo but the observed difference was not statistically significant. Other variables monitored such as weight, heart rate, respiratory rate, hematology, liver and kidney function biochemical parameters did not show significant changes with either treatment. Cholesterol and SGPT increased significantly with placebo 4-week therapy. Cholesterol decreased with garlic administration but this was not statistically significant. Both garlic and placebo capsules were found acceptable as to taste, smell and ease of swallowing. Both treatments evoked few adverse experiences such as drowsiness, epigastric pain and flatulence. This study seem to support the trend in non-pharmacologic approach of diet modification and change in life style in the management of mild hypertension. (Author) Note: A clinical study conducted on garlic as hypocholesterolemic.

Publication Type
Research Project
Date

Objectives

General: To determine the efficacy and acceptability of low-dose garlic as an anti-hypertensive agent versus placebo based on a clilical trial on PGH out-patient with mild hypertension.Specific: To characterize the patient with mild hypertension participating in the study as to age, sex, duration, of illness, diet and common symptoms;2. To compare the efficacy of low-dose garlic (250 mg BID) capsule versus the placebo for the treatment of mild hypertension;3. To determine the acceptability of low-dose garlic;4. To describe any adverse experience if any, with garlic of placebo therapy.

LocationLocation CodeAvailable FormatAvailability
Philippine Council for Health Research and Development Library RDR RS 164 M11 1989/PRP 162 Abstract Print Format (Request Document)